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The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas showed slight erythema and extreme dryness. Mean data for 3 donors and 16 replicates point out a plateau in receptor fluid focus between 24 and forty eight h, as mirrored by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
The elimination was biphasic, with half-lives of 18—21 min and eight. The 14 C activity was quickly distributed in main tissues similar to muscular tissues, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new data being provided in the middle of the OECD evaluation will be offered to the IPCS so that an addendum may be ready for consideration.
Furthermore, persistent studies with fish and Daphnia have been conducted. For the toxicity to aquatic plants, no guideline examine is on the market. However, considering the obtainable studies for toxicity to aquatic crops, the NOEC for algae can be assumed to be higher than that for Daphnia magna. Exposure to resorcinol by the use of peeling brokers presents an acute publicity scenario where the particular person is uncovered to a high focus 7. Acute effects have been described beneath these circumstances.
Thyroid glands from all surviving F 0 mother and father have been examined microscopically, and mind measurements were carried out on all exposed F 1 pups and those F 1 pups chosen for behavioural testing. There were no significant intercourse differences. In females, a greater proportion was excreted as sulfate conjugate, whereas males excreted the next proportion of a diconjugate both sulfate and glucuronide teams. From these information, the authors concluded that male rats have a higher capability for glucuronidation than females.
The third research, performed in , included of active staff. In topics males, thirteen women with a mean age of 37 years, both laboratory and other checks, including medical examination, have been done; no irregular thyroid glands or modifications in T four values have been present in any of the themes in comparison with regular values Bauer, The above knowledge are limited because of small examine sizes, lack of comparison groups, lacking current and historical management knowledge, and lacking info regarding potential publicity classes. In a examine in a plant producing resorcinol by sulfonation of benzene — and likewise producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — employees have been exposed primarily to resorcinol, however the publicity to different agents was not measured for publicity ranges, see section 6. In this plant, three cross-sectional research have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary perform, haematology, and medical chemistry were carried out with of persons actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have higher circulating ranges of TSH than females.
There were no revealed animal research exhibiting thyroidal results with a dose—response relationship that could be used for a tolerable intake. In the body of a full life cycle toxicity test OECD TG , Lima noticed no antagonistic results after forty eight h of exposure at the highest focus tested, zero. Furthermore, Cronin et al. The fish and pond snails were placed immediately into the aquaria, while the remaining five species were segregated in different baskets and suspended within the aquaria. The solely investigation into this finish-point is that from the dose range-finding research reported in sections 8.

In both species, there have been no antagonistic effects on last imply body weights, haematology, or scientific chemistry parameters, and no chemical-related gross or microscopic lesions were observed. In one other research, rats have been exposed to zero or zero. No thyroid hormone measurements were performed.

• For the thyroid, a non-statistically important improve in TSH ranges was reported for interim males, however not at scheduled necropsy.





• Fifty per cent of survivors have been sacrificed 1 week later, and blood and urine samples have been taken.





• A concentration of 0.





• In both species, there were no antagonistic results on last imply body weights, haematology, or clinical chemistry parameters, and no chemical-associated gross or microscopic lesions have been noticed.





• In high-dose teams, a decrease in physique weight and decreased survival had been noted.

Determination of resorcinol conjugates within the h urine samples after 14 days of steady product remedy confirmed that a maximal 23 mg 2. Assuming a physique weight of sixty four kg IPCS, gives an exposure estimate of zero. In a report primarily based on consumer analysis information Gans, , under affordable maximum-use situations i.
Although thyroid effects are a significant end-level in both human case-studies and animal research, there is a lack of consistency in the leads to the animal studies. Resorcinol brought on no opposed results in a number of copy and developmental toxicity studies in rats and rabbits. Resorcinol is not considered to be genotoxic.

There is no guideline research on toxicity for aquatic vegetation out there. As only one concentration was examined, the study can't be used in the danger evaluation. There are a number of research obtainable on acute toxicity to completely different fish species.

There are differences in thyroid physiology between people and animals. The weight of evidence means that rodents are more sensitive to thyroid results than people.

Other pores and skin results were hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic treatment-related lesions. With resorcinol, a number of initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were handled with two subcutaneous injections of. In a study carried out by Hasegawa et al.
The effects have been more pronounced at seventy two h. The irritation index was given as four. However, owing to lacking correlating histopathological changes in the three levels of the brain examined and within the absence of a dose—response relationship, other indicators of developmental delay, or different adjustments in CNS operate, these effects weren't considered as conclusive evidence of a change in CNS operate. In the next two-generation reproductive toxicity research RTF, , these finish-factors weren't investigated. No resorcinol-related results on F 0 and F 1 pup survival or the final physical situation of the pups through the pre-weaning period have been noticed.
Apart from one constructive single case-examine Vilaplana et al. In these circumstances, the tested focus of resorcinol was zero. The information are summarized in Table eight. Data regarding the totally different job classes weren't offered.